Jacobs J M, Miller R H, Cavanagh J B
Acta Neuropathol. 1979 Oct;48(1):1-9. doi: 10.1007/BF00691784.
Rats were given isoniazid either in a single large dose or continuously in drinking water and killed 5--105 days later. The distribution of degenerating fibres in various nerves (sensory and mixed) and in various sites along nerves and spinal roots was studied by light and electron microscopy. It was found that sensory nerves tended to be less affected than motor, and degeneration was more proximal in the latter. It was concluded that the pattern of degeneration and regeneration supported the view that the initial metabolic lesion is in the axon, rather than in the cell body.
给大鼠单次大剂量注射异烟肼或让其持续饮用含异烟肼的水，5至105天后将其处死。通过光学显微镜和电子显微镜研究了各种神经（感觉神经和混合神经）以及沿神经和脊髓神经根不同部位的变性纤维分布。结果发现，感觉神经比运动神经受影响较小，而运动神经的变性更靠近近端。得出的结论是，变性和再生模式支持最初的代谢损伤位于轴突而非细胞体这一观点。
