Darcel F, Chatel M, Gautris P, Labarre J F
Labortoire de Neuropathologie, C.H.U., Rennes, France.
Anticancer Res. 1990 Nov-Dec;10(6):1563-9.
Since the polyamine metabolism system is very active in proliferative glioma cells, polyamine linked drugs are to be considered as potential antineoplastic agents against malignant gliomas. This study reports the trial of a new compound lineage, the Polyamine Linked Cyclophosphazenes, on human glioblastoma heterografts in nu-nu mice. Two agents are tested: DIAM 3 and DIAM 4. Both show an important antineoplastic action either on a chronic treatment schedule or as single dose. Systemic tolerance is satisfactory.
由于多胺代谢系统在增殖性胶质瘤细胞中非常活跃，因此多胺连接药物被认为是对抗恶性胶质瘤的潜在抗肿瘤药物。本研究报告了一种新的化合物谱系——多胺连接环磷腈，在无胸腺裸鼠人胶质母细胞瘤异种移植模型上的试验。测试了两种药物：DIAM 3和DIAM 4。无论是在长期治疗方案中还是单剂量使用时，两者都显示出重要的抗肿瘤作用。全身耐受性良好。
