Fu Tingming, Lu Jin, Guo Liwei, Zhang Lianjun, Cai Xueping, Zhu Huaxu
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
J Nanosci Nanotechnol. 2012 May;12(5):3997-4006. doi: 10.1166/jnn.2012.5826.
Mesoporous silica SBA-15 (SC) and template occluded SBA-15 (SP) were used to increase the bioavailability of silybin, an extremely poorly water soluble drug. Silybin was introduced into SC and SP by assembling or self-assembling methods. The results of X-ray powder diffraction, differential scanning calorimetry (DSC) and N2 adsorption-desorption experiment indicated that amorphous silybin was successfully introduced into the mesopores in both SC and SP samples. The transmission electron micrograph (TEM) images revealed that the structure of the mesoporous materials was not destroyed after the drug loading. Results of dissolution rate tests and animal experiments showed that both SC and SP can significantly improve the bioavailability of silybin, SP was thus preferred because the template needs not to be removed by calcination or extraction.
介孔二氧化硅SBA - 15（SC）和模板封闭的SBA - 15（SP）被用于提高水飞蓟宾的生物利用度，水飞蓟宾是一种水溶性极差的药物。通过组装或自组装方法将水飞蓟宾引入SC和SP中。X射线粉末衍射、差示扫描量热法（DSC）和N2吸附 - 脱附实验结果表明，无定形水飞蓟宾成功引入到SC和SP样品的介孔中。透射电子显微镜（TEM）图像显示，载药后介孔材料的结构未被破坏。溶出度试验和动物实验结果表明，SC和SP均可显著提高水飞蓟宾的生物利用度，因此SP更受青睐，因为无需通过煅烧或萃取去除模板。
