do Sameiro Faria Maria, Ribeiro Sandra, Nascimento Henrique, Rocha-Pereira Petronila, Miranda Vasco, Mendonça Denisa, Quintanilha Alexandre, Costa Elísio, Belo Luís, Santos-Silva Alice
FMC, Dinefro - Diálises e Nefrologia - SA , Portugal.
Scand J Urol Nephrol. 2012 Dec;46(6):461-5. doi: 10.3109/00365599.2012.708943. Epub 2012 Aug 2.
The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction.
In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured.
Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer.
Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.
