University of Belgrade, Belgrade, Serbia.
J Microencapsul. 2013;30(2):151-60. doi: 10.3109/02652048.2012.704954. Epub 2012 Aug 1.
Poly(ε-caprolactone) (PCL), a biodegradable and biocompatible aliphatic polyester has a great potential as a drug carrying material in controlled drug delivery/release systems. The most simple and economical way to tailor the release profile of active substances from biodegradable polymer matrix is by the addition of the second polymeric component in the polymer matrix, i.e. by blending. This study describes the preparation and characterization of a carbamazepine-loaded microspheres by the use of PCL blended with poly(ethylene oxide) as a drug carrying material. By the use of two-component hydrophilic/hydrophobic polymer blend as a microspheres' matrix material, release profile of the drug can be modified and dictated. The microspheres prepared by classical oil-in-water emulsion solvent evaporation technique were characterized with respect to particle size and morphology, polymer matrix composition, encapsulation efficiency, physical state of the drug and in vitro release behaviour. It was presented that the release profile can be modified by the presence and the amount of hydrophilic component in the starting formulation of microspheres.
聚（ε-己内酯）（PCL）是一种可生物降解和生物相容的脂肪族聚酯，作为控制药物释放/释放系统中的药物载体材料具有很大的潜力。通过在聚合物基质中添加第二种聚合物成分，即共混，来调整活性物质从可生物降解聚合物基质中释放的情况是最简单、最经济的方法。本研究描述了使用 PCL 与聚（氧化乙烯）共混作为药物载体材料制备和表征卡马西平负载微球。通过使用两亲性亲水/疏水聚合物共混物作为微球的基质材料，可以修饰和控制药物的释放曲线。通过经典的油包水乳液溶剂蒸发技术制备的微球在粒径和形态、聚合物基质组成、包封效率、药物的物理状态和体外释放行为方面进行了表征。结果表明，通过微球起始配方中亲水性成分的存在和数量可以改变释放曲线。
