Glozman V N
Antibiot Khimioter. 1990 Jul;35(7):50-2.
Twenty eight patients aged 18 to 40 years with urogenital infections complicated by orchiepididymitis were examined immunologically. The use of specific monoclonal antibodies OKT-4+ and OKT-8 revealed lower contents of T-helper cells (Thc) (23.33 +/- 9.7%) and higher contents of T-suppressor cells (Tsc) (41.17 +/- 13.41%) in them as compared to those in healthy volunteers (18 persons) and patients with noncomplicated urogenital infections (19 persons). There was a significant decrease in the immunoregulatory index (IRI): Thc/Tsc (0.68 +/- 0.33) reached in some patients the ratio observed in persons infected with the HIV (0.6 +/- 0.2) and an increase in the contents of circulating immune complexes (CIC) (28.5 +/- 2.0 arbitrary units against the normal of 10.0 +/- 0.7). Enzyme therapy including the use of chymotrypsin and trypsin manufactured in the USSR in doses of 10 mg each administered intramuscularly once a day or in doses of 5 mg each administered intramuscularly twice a day for 10 days promoted normalization of the impaired immunity indices (Thc 44.0 +/- 10.51%, Tsc 31.5 +/- 11.26%, IRI 1.53 +/- 0.33 and CIC 12.1 +/- 0.74 arbitrary units). Therefore, the enzymes had an immunomodulating effect. It is likely that they will be useful in treatment of infectious inflammatory processes accompanied by analogous immune disorders which makes the enzyme immunocorrection more applicable in treatment of various pathological processes.
对28例年龄在18至40岁、患有泌尿生殖系统感染并伴有睾丸炎附睾炎的患者进行了免疫学检查。与健康志愿者（18人）和非复杂性泌尿生殖系统感染患者（19人）相比，使用特异性单克隆抗体OKT-4 +和OKT-8检测发现，这些患者体内的T辅助细胞（Thc）含量较低（23.33 +/- 9.7%），而T抑制细胞（Tsc）含量较高（41.17 +/- 13.41%）。免疫调节指数（IRI）：Thc/Tsc（0.68 +/- 0.33）显著降低，部分患者达到了感染HIV者的比例（0.6 +/- 0.2），循环免疫复合物（CIC）含量增加（28.5 +/- 2.0任意单位，而正常为10.0 +/- 0.7）。酶疗法，包括使用苏联生产的胰凝乳蛋白酶和胰蛋白酶，剂量为每次10 mg，每天肌肉注射一次，或每次5 mg，每天肌肉注射两次，持续10天，促使受损免疫指标恢复正常（Thc为44.0 +/- 10.51%，Tsc为31.5 +/- 11.26%，IRI为1.53 +/- 0.33，CIC为12.1 +/- 0.74任意单位）。因此，这些酶具有免疫调节作用。它们可能对治疗伴有类似免疫紊乱的感染性炎症过程有用，这使得酶免疫校正更适用于治疗各种病理过程。
