Kuz'mina L M, Krasnova T P, Lysko A V, Vostrikova V N, Bushueva O A, Mal'tsev N I
Antibiot Khimioter. 1990 Jul;35(7):8-12.
The study provided data on the rate of consumption of the main nutrients by the rifamycin-producing culture in relation to their content in the initial medium. A program for feeding ammonium sulfate and cornsteep liquor and joint control of both the nutrients was developed and tested. The results of the testing confirmed the practicable precision of the feeding. The control of cornsteep liquor and ammonium sulfate concentrations with the program allowed to increase the yield of rifamycin B by 15 and 20%, respectively. The joint control increased the level of the required product by 25%.
该研究提供了关于利福霉素产生菌对主要营养物质的消耗速率与其在初始培养基中的含量之间关系的数据。开发并测试了一个用于添加硫酸铵和玉米浆以及对这两种营养物质进行联合控制的程序。测试结果证实了该添加程序的实际精度。使用该程序控制玉米浆和硫酸铵的浓度，可使利福霉素B的产量分别提高15%和20%。联合控制使所需产物的水平提高了25%。
