路易体痴呆和阿尔茨海默病轻度认知障碍的神经精神症状。
Neuropsychiatric symptoms in mild dementia with lewy bodies and Alzheimer's disease.
机构信息
Department of Psychiatry, Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
出版信息
Dement Geriatr Cogn Disord. 2012;34(1):1-6. doi: 10.1159/000339590. Epub 2012 Jul 31.
BACKGROUND/AIMS: To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB).
METHODS
Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups using non-parametric tests.
RESULTS
The DLB patients had a higher NPI totalscore (median 24 vs. 11.5, p < 0.005), more numerous symptoms (median 5 vs. 4, p = 0.001) and more clinically significant symptoms (3 vs. 1, p = 0.001). They also had higher item hallucinations (6 vs. 2, p < 0.005) and apathy (7 vs. 5, p = 0.002) subscores. Caregivers scored higher on the NPI total caregiver distress scale (12.5 vs. 6, p = 0.003).
CONCLUSIONS
In mild dementia, DLB patients have more neuropsychiatric symptoms and more associated caregiver distress compared with AD.
背景/目的：比较阿尔茨海默病（AD）和路易体痴呆（DLB）患者的神经精神症状。
方法
使用神经精神问卷（NPI）评估轻度 DLB（n = 57）和 AD（n = 126）患者的神经精神症状和照料者困扰，并使用非参数检验比较两组之间的差异。
结果
DLB 患者的 NPI 总分更高（中位数 24 分 vs. 11.5 分，p < 0.005），症状更多（中位数 5 分 vs. 4 分，p = 0.001），更具临床意义的症状（3 分 vs. 1 分，p = 0.001）。他们的幻觉（6 分 vs. 2 分，p < 0.005）和淡漠（7 分 vs. 5 分，p = 0.002）分项得分也更高。NPI 总分照料者困扰量表上，照料者评分更高（12.5 分 vs. 6 分，p = 0.003）。
结论
在轻度痴呆中，与 AD 相比，DLB 患者的神经精神症状更多，且相关照料者困扰更严重。
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