Svendsboe Ellen, Terum Toril, Testad Ingelin, Aarsland Dag, Ulstein Ingun, Corbett Anne, Rongve Arvid
Department of Nursing, Stord/Haugesund University College, Stord, Norway.
Department of Neurobiology, Care Sciences and Society, Karolinska Institute, SE-141 83, Huddinge, Sweden.
Int J Geriatr Psychiatry. 2016 Sep;31(9):1075-83. doi: 10.1002/gps.4433. Epub 2016 Jan 14.
To characterise the differences in caregiver distress between carers of people diagnosed with dementia with Lewy bodies (DLB) and people with Alzheimer's disease (AD), with a view to differentiating and improving support for caregivers.
This study is a part of two larger Norwegian studies, DemVest (n = 265) and The Norwegian Dementia Register (n = 2220), with data from caregivers and people diagnosed with AD (n = 100) and DLB (n = 86) between 2005 and 2013. The average age was 74.9 years (SD = 7.8). Caregiver distress was rated by the Relative Stress Scale. Diagnosis of the person receiving care was based on a comprehensive standardised assessment program (International Classification of Diseases, Revision 10 or Diagnostic and Statistical Manual for Mental Disorders, fourth edition). Additional data collected from people receiving care were neuropsychiatric symptoms, comorbidity and activities of daily living (ADL) score. Linear regression analyses were applied, first unadjusted and then in stepwise-adjusts in addition to descriptive analyses.
Caregivers to people with AD (20.2%) and 40% of caregivers for people with DLB experienced moderate or high caregiver burden with an increased risk of psychiatric disorders in the early stage of dementia. High Relative Stress Scale (RSS) total scores in caregivers was significantly associated with neuropsychiatric symptoms (Neuropsychiatric Inventory, p = 0.004) and also with impaired ADL functioning (Rapid Disability Rating Scale-2, p < 0.0005).
Caregiver distress differed (RSS total, p = 0.005) between people caring for someone with AD (15.0) and those caring for someone with DLB (19.9). These findings have direct implications for the needs and resources that could be available for these individuals and indicate the need for further research into caregiver burden in carers to people with DLB. Copyright © 2016 John Wiley & Sons, Ltd.
Cohorts were ethically approved by the Regional Ethics Committee for Medical Research Ethics in Eastern and Western Norway.
描述路易体痴呆（DLB）患者照料者与阿尔茨海默病（AD）患者照料者在照料者痛苦程度上的差异，以便区分并改善对照料者的支持。
本研究是两项更大规模挪威研究的一部分，即DemVest（n = 265）和挪威痴呆症登记处（n = 2220），数据来自2005年至2013年间的照料者以及被诊断为AD（n = 100）和DLB（n = 86）的患者。平均年龄为74.9岁（标准差 = 7.8）。照料者痛苦程度通过相对压力量表进行评定。接受照料者的诊断基于全面的标准化评估程序（国际疾病分类第10版或精神障碍诊断与统计手册第四版）。从接受照料者处收集的其他数据包括神经精神症状、合并症和日常生活活动（ADL）评分。应用线性回归分析，首先进行未调整分析，然后除描述性分析外还进行逐步调整分析。
AD患者的照料者中有20.2%以及DLB患者的照料者中有40%在痴呆症早期经历了中度或高度的照料者负担，且患精神疾病的风险增加。照料者的相对压力量表（RSS）总分与神经精神症状（神经精神症状问卷，p = 0.004）以及ADL功能受损（快速残疾评定量表 - 2，p < 0.0005）显著相关。
照料AD患者的照料者（15.0）与照料DLB患者的照料者（19.9）在照料者痛苦程度上存在差异（RSS总分对比，p = 0.005）。这些发现对于这些个体可获得的需求和资源具有直接影响，并表明需要进一步研究DLB患者照料者的照料负担。版权所有© 2016约翰威立父子有限公司。
这些队列研究获得了挪威东部和西部地区医学研究伦理区域伦理委员会的伦理批准。
