Servicio de Cirugía Torácica y Trasplante Pulmonar, Complejo Hospitalario Universitario de A Coruña, A Coruña, España.
Med Intensiva. 2013 Jan-Feb;37(1):44-9. doi: 10.1016/j.medin.2012.05.011. Epub 2012 Jul 31.
Immunosuppression in transplantation has experienced changes in recent years as a result of the introduction of new drugs that act upon the different pathways of the host immune response with the purpose of securing more individualized immune suppression, with fewer side effects. Although following in the steps of other solid organ transplant modalities, lung transplantation, because of its special characteristics, has not yielded similar middle- and long-term results. Improved understanding of the underlying rejection mechanisms, the pharmacodynamic control of drugs, new administration routes designed to reduce the side effects, and new drug substances or immune modulating processes will all contribute to improve the expectations associated to lung transplantation in the near future.
近年来，由于引入了作用于宿主免疫反应不同途径的新药，移植中的免疫抑制发生了变化，目的是实现更个体化的免疫抑制，同时减少副作用。尽管肺移植效仿了其他实体器官移植方式，但由于其特殊特征，并未产生类似的中长期结果。对潜在排斥机制的深入了解、药物的药效学控制、旨在减少副作用的新给药途径以及新的药物物质或免疫调节过程，都将有助于提高人们对肺移植的期望。
