Green S
Imperial Chemical Industries, Central Toxicology Laboratory, Macclesfield, Cheshire, England.
J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):747-51. doi: 10.1016/0960-0760(90)90415-h.
The oestrogen receptor is a member of a supergene family that includes receptors for steroid and thyroid hormones, vitamin D3, and retinoic acid. A number of additional members of the family have been cloned where the putative ligand remains to be identified. The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences (oestrogen response elements) located in the vicinity of oestrogen-regulated genes. Regions of the receptor responsible for hormone-binding. DNA-binding and activation of transcription, have been identified. The anti-oestrogen, tamoxifen (Nolvadex), behaves as a weak oestrogen agonist. A model, based upon our current understanding of the molecular mechanism of oestrogen action, will be presented to explain the cell and gene specific effects of some anti-oestrogens.
雌激素受体是一个超基因家族的成员，该家族包括类固醇和甲状腺激素、维生素D3及视黄酸的受体。该家族的许多其他成员已被克隆，但推定的配体仍有待确定。雌激素受体是一种配体激活的转录因子，通过与位于雌激素调节基因附近的短DNA序列（雌激素反应元件）结合来调节特定基因的表达。已确定了受体中负责激素结合、DNA结合及转录激活的区域。抗雌激素药物他莫昔芬（诺瓦得士）表现为一种弱雌激素激动剂。将基于我们目前对雌激素作用分子机制的理解提出一个模型，以解释某些抗雌激素药物对细胞和基因的特异性作用。
