Sokol Vesna, Zlopasa Gordan, Herman Mislav, Planinić Pavao, Micevska Ana
University of Zagreb, Zagreb University Hospital Center, Department of Obstetrics and Gynaecology, Zagreb, Croatia.
Coll Antropol. 2012 Jun;36(2):677-9.
In Marfan syndrome, with dilatation of the aortic root secondary to an underlying connective tissue defect, pregnancy can cause hemodynamic stress leading to the development of an aortic aneurysm and even a fatal aortic dissection. In the presence of existing aortic root enlargement and a family history of aortic dissection, preventative elective surgery is suggested. Aortic root replacement with or without a valve-sparing procedure is superior to total aortic root replacement with prosthetic valve/tube graft. It provides excellent survival with low rates of aortic - valve related complications.
在马凡综合征中，由于潜在的结缔组织缺陷导致主动脉根部扩张，妊娠会引起血流动力学应激，进而导致主动脉瘤甚至致命的主动脉夹层形成。在存在主动脉根部已扩大及主动脉夹层家族史的情况下，建议进行预防性择期手术。保留或不保留瓣膜的主动脉根部置换术优于带人工瓣膜/人工血管的全主动脉根部置换术。它能带来良好的生存率，且主动脉瓣相关并发症发生率低。
