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[组织细胞性坏死性淋巴结炎:(库库奇-藤本病):一项诊断挑战]

[Histiocytic necrotizing lymphadenitis: (Kukuchi-Fujimoto disease): a diagnostic challenge].

作者信息

Antunes Inês, Botella Arturo, Marques Filipa, Araújo Inês, Abreu Ana, Cardiga Rosa, Leitão Ana, Fonseca Cândida, Ceia Fátima

机构信息

Serviço de Medicina Interna, Hospital São Francisco Xavier (CHLO), Lisbon, Portugal.

出版信息

Acta Med Port. 2011 Dec;24 Suppl 3:681-4. Epub 2011 Dec 31.

Abstract

Kikuchi-Fujimoto disease, also called Histiocytic necrotizing lymphadentis, is a rare, benign and self-limited disease, with unknown etiology, that affects mainly young women, and is characterized by adenopathy (usually localized in the cervical region) and fever. Diagnosis is based on histopathological findings in ganglionar tissue obtained in excisional biopsy, which allows, in most cases, the differential diagnosis with other similar clinical conditions, but which have a completely different clinical evolution and therapeutic needs. We report a case of a twenty four year old woman with persistent cervical lymphadenopathy, in which histopathological examination followed by immunohistochemical analysis of ganglionar tissue revealed to be Kikuchi-Fujimoto disease.

摘要

菊池-藤本病,又称组织细胞坏死性淋巴结炎,是一种罕见的、良性的自限性疾病,病因不明,主要影响年轻女性,其特征为淋巴结病(通常局限于颈部)和发热。诊断基于切除活检获取的淋巴结组织的组织病理学检查结果,在大多数情况下,这有助于与其他类似临床病症进行鉴别诊断,而这些病症具有完全不同的临床病程和治疗需求。我们报告一例24岁女性持续性颈部淋巴结病的病例,其中淋巴结组织的组织病理学检查及免疫组化分析显示为菊池-藤本病。

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