Coelho Joana, Gonçalves Carla, Leitão Sara, Marques Dos Santos R, Nascimento Costa J
Serviço de Medicina Interna, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
Acta Med Port. 2011 Dec;24 Suppl 3:729-34. Epub 2011 Dec 31.
Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group.
左氧氟沙星在医学实践中常用，用于治疗合并症患者的肺炎。虽然它通常耐受性良好且安全，但它具有一种众所周知但很少被报道、特征描述不足且识别不清的肝毒性，其特征尚不明确。在暴发性肝炎病例中，胆汁淤积发作显示出明显的良性进展。它干扰糖代谢的能力也广为人知，这些事件的易感因素包括年龄、多种疾病的存在以及多种药物治疗。糖尿病与肝毒性之间的联系尚未确定。尽管如此，文献中几例病例报告以及在胰岛素治疗的糖尿病患者中发现的两例病例，使人相信这是一个高风险群体。
