Department of Ophthalmology, Centro Hospitalar Porto, Praça Prof. Abel Salazar, Porto, Portugal.
Amyloid. 2012 Sep;19(3):152-5. doi: 10.3109/13506129.2012.712075. Epub 2012 Aug 3.
Liver transplanted patients with familial amyloidosis (FAP) patients develop earlier presbyopia due to the deposition of amyloid on the anterior capsule of the lens. Despite normal visual acuity of 20/20 Snellen chart, some patients reported complaints of impaired vision. The aim of this study is to investigate the visual spatial contrast sensitivity in these patients. This is a retrospective, nonrandomized study. Spatial contrast sensitivity was performed in both eyes of 25 FAP patients with best correct visual acuity of 20/20 Snellen chart. In each patient, one eye had visible opacification of anterior capsule of the lens. FAP patients had poorer visual contrast sensitivity than normal even in absence of visible opacification of the anterior capsule of the lens. Comparing eyes with visible opacification of anterior capsule of the lens with eyes without visible opacification of the anterior capsule of the lens, a worse visual sensitivity was observed at all frequencies tested. This occurred with similar lacrimal function in both groups. The eyes of FAP patients have decreased spatial contrast sensitivity which is worse in presence of visible opacification of the anterior capsule of the lens. This could explain the visual complaints in presence of normal visual acuity by Snellen chart.
肝移植患者发生家族性淀粉样变性（FAP）后，由于前囊晶状体的淀粉样物质沉积，会更早出现老视。尽管 Snellen 图表的正常视力为 20/20，但一些患者报告视力受损。本研究旨在研究这些患者的视觉空间对比敏感度。这是一项回顾性、非随机研究。对 25 名 FAP 患者的双眼进行了最佳矫正视力为 20/20 的 Snellen 图表的空间对比敏感度检查。在每个患者中，一只眼的前囊晶状体有可见的混浊。即使在前囊晶状体没有可见混浊的情况下，FAP 患者的视觉对比敏感度也比正常人差。比较前囊晶状体有可见混浊的眼睛和前囊晶状体无可见混浊的眼睛，在所有测试的频率下，观察到较差的视觉敏感性。两组的泪液功能相似。FAP 患者的眼睛空间对比敏感度下降，在前囊晶状体有可见混浊时更差。这可以解释 Snellen 图表正常视力下的视觉主诉。
