Frankel Adam, Nancarrow Derek, Wayte Nicola, Barbour Andrew
School of Medicine, University of Queensland, Woolloongabba, Queensland, Australia.
ANZ J Surg. 2012 Sep;82(9):599-606. doi: 10.1111/j.1445-2197.2012.06144.x. Epub 2012 Aug 1.
While not being considered a common cancer, since 1975 oesophageal adenocarcinoma (OAC) has had the fastest-rising incidence of any malignancy in Caucasian Western populations. In the absence of major improvements in treatment since this rise began, the number of deaths has also increased rapidly. In contrast, there have been significant advances in basic science in this period. One such advance is the discovery of DNA copy number aberrations (CNAs), and their potential role in carcinogenesis. The study of CNAs offers the potential to answer fundamental clinical questions in OAC, which in turn may lead to improved diagnosis, staging and treatment. This review outlines current clinical dilemmas in OAC, discusses the role that CNAs have been shown to play to date and highlights potential future applications.
虽然食管腺癌（OAC）不被视为常见癌症，但自1975年以来，它在西方白种人群中是所有恶性肿瘤中发病率上升最快的。自发病率开始上升以来，由于治疗方面没有重大改善，死亡人数也迅速增加。相比之下，这一时期基础科学有了显著进展。其中一项进展是发现了DNA拷贝数畸变（CNA）及其在致癌过程中的潜在作用。对CNA的研究为回答OAC的基本临床问题提供了潜力，这反过来可能会改善诊断、分期和治疗。本综述概述了OAC当前的临床困境，讨论了迄今为止CNA已被证明所起的作用，并强调了潜在的未来应用。
