N-α-椰油酰-L-精氨酸乙酯DL-焦谷氨酸盐作为乙型肝炎表面抗原的灭活剂。
N-alpha-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt, as an inactivator of hepatitis B surface antigen.
作者信息
Sugimoto Y, Toyoshima S
出版信息
Antimicrob Agents Chemother. 1979 Sep;16(3):329-32. doi: 10.1128/AAC.16.3.329.
N-alpha-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt (CAE), exhibited a strong inactivating effect on hepatitis B surface antigen. Concentrations of CAE required for 50 and 100% inactivation of the antigen were 0.01 to 0.025% and 0.025 to 0.05% respectively. CAE completely inactivated hepatitis B surface antigen at the lowest concentration compared with various compounds including about 500 amino acid derivatives, sodium hypochlorite, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, and some detergents. Furthermore, CAE inactivated vaccinia virus, herpes simplex virus, and influenza virus, whereas poliovirus was not inactivated at all. The results suggest that the inactivating effects of CAE are related to interaction with lipid-containing viral envelopes.
N-α-椰油酰-L-精氨酸乙酯DL-焦谷氨酸盐（CAE）对乙型肝炎表面抗原有很强的灭活作用。使该抗原50%和100%失活所需的CAE浓度分别为0.01%至0.025%和0.025%至0.05%。与包括约500种氨基酸衍生物、次氯酸钠、2,4,4'-三氯-2'-羟基二苯醚和一些去污剂在内的各种化合物相比，CAE在最低浓度下就能完全灭活乙型肝炎表面抗原。此外，CAE能灭活痘苗病毒、单纯疱疹病毒和流感病毒，而脊髓灰质炎病毒则完全未被灭活。结果表明，CAE的灭活作用与它和含脂质病毒包膜的相互作用有关。
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