氨基酸与肽。XXVII. 植物螯合素相关肽的合成及其重金属结合特性研究。

Amino acids and peptides. XXVII. Synthesis of phytochelatin-related peptides and examination of their heavy metal-binding properties.

作者信息

Matsumoto Y, Okada Y, Min K S, Onosaka S, Tanaka K

机构信息

Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Nishi-ku, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2364-8. doi: 10.1248/cpb.38.2364.

DOI:10.1248/cpb.38.2364

PMID:2285972

Abstract

Phytochelatin (PC)-related peptides were prepared by a conventional solution method and their heavy metal-binding properties were examined. Different from the Cu2+ and Cu+ -binding properties of metallothionein (MT)-related peptides, the Cu2+ and Cu+ -binding properties of PC-related peptides were fairly dependent on structure. It is of interest that gamma-Glu-Cys-Gly (glutathione) exhibited quite different Cu2+ and Cu+ -binding properties from those of other PC-related peptides and its binding abilities were comparable to those of MT-related peptides. The Cd2+ -binding properties of glutathione were similar to those of Cys, and the Cd2+ -binding abilities of PC-related peptides increased in proportion to the increase of gamma-Glu-Cys peptide unit.

摘要

通过传统溶液法制备了植物螯合肽（PC）相关肽，并研究了它们的重金属结合特性。与金属硫蛋白（MT）相关肽的Cu2+和Cu+结合特性不同，PC相关肽的Cu2+和Cu+结合特性相当依赖于结构。有趣的是，γ-谷氨酰-半胱氨酸-甘氨酸（谷胱甘肽）表现出与其他PC相关肽截然不同的Cu2+和Cu+结合特性，其结合能力与MT相关肽相当。谷胱甘肽的Cd2+结合特性与半胱氨酸相似，且PC相关肽的Cd2+结合能力随γ-谷氨酰-半胱氨酸肽单元的增加而按比例增加。