不同含水量的 Sofnolime 在两种七氟醚吸入诱导技术中对复合物 A 的产量有不同的影响。

Sofnolime with different water content causes different effects in two sevoflurane inhalational induction techniques with respect to the output of compound-A.

机构信息

Department of Anesthesiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.

出版信息

Int J Med Sci. 2012;9(6):435-40. doi: 10.7150/ijms.4436. Epub 2012 Jul 25.

DOI:10.7150/ijms.4436

PMID:22859903

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3410362/

Abstract

OBJECTIVE

During sevoflurane anesthesia with Sofnolime for CO(2) absorption, the factors affecting the production of compound A (a chemical is nepherotoxic) are still not clear. This study is designed to investigate the effects of different fresh gas flow during induction, the vital capacity induction (VCI) vs. the tidal volume breath induction (TBI) on the compound-A production with a fresh Sofnolime or a dehydrated Sofnolime using a simulated lung model.

METHOD

The experiments were randomly divided into four groups: group one, VCIf, vital capacity fresh gas inflow with fresh Sofnolime; group two, TBIf, tidal volume breath fresh gas inflow with fresh Sofnolime; group three, VCId, vital capacity fresh gas inflow with dehydrated Sofnolime, and group four, TBId, tidal volume breath fresh gas inflow with dehydrated Sofnolime. The inspired sevoflurane was maintained at 8%, the concentrations of compound-A were assayed using Gas-spectrum technique, and Sofnolime temperatures were monitored at 1-min intervals throughout the experiment.

RESULTS

The mean and maximum concentrations of compound A were significantly higher in the vital capacity group than the tidal volume breath group (P<0.01). At the beginning of anesthesia maintenance, the compound-A concentration in group VCIf was 36.28±6.13 ppm, which was significantly higher than the 27.32±4.21 ppm observed in group TBIf (P<0.01). However, these values decreased to approximately 2 ppm in the dehydrated Sofnolime groups. Sofnolime temperatures increased rapidly in the dehydrated Sofnolime groups but slowly in the fresh Sofnolime groups.

CONCLUSION

With fresh Sofnolime, vital capacity induction increased compound-A production in the circuit system compared with tidal volume breath induction. However, with dehydrated Sofnolime, the effects of the two inhalation induction techniques on compound-A output were not significantly different.

摘要

目的

在使用 Sofnolime 吸收二氧化碳的七氟醚麻醉期间，影响化合物 A（一种具有肾毒性的化学物质）生成的因素尚不清楚。本研究旨在通过模拟肺模型，探讨不同潮气容积诱导（TBI）与潮气量预充肺诱导（VCI）对使用新鲜 Sofnolime 或脱水 Sofnolime 时复合 A 生成的影响。

方法

实验随机分为四组：第 1 组，VCI-f，新鲜 Sofnolime 下的潮气容积新鲜气体流入；第 2 组，TBI-f，新鲜 Sofnolime 下的潮气量呼吸新鲜气体流入；第 3 组，VCI-d，脱水 Sofnolime 下的潮气容积新鲜气体流入；第 4 组，TBI-d，脱水 Sofnolime 下的潮气量呼吸新鲜气体流入。吸入七氟醚维持在 8%，采用气相谱技术测定复合 A 的浓度，并在整个实验过程中每隔 1 分钟监测 Sofnolime 温度。

结果

潮气量组的复合 A 平均浓度和最高浓度明显高于潮气量呼吸组（P<0.01）。在麻醉维持开始时，VCI-f 组的复合 A 浓度为 36.28±6.13ppm，明显高于 TBI-f 组的 27.32±4.21ppm（P<0.01）。然而，在脱水 Sofnolime 组中，这些值降低至约 2ppm。脱水 Sofnolime 组的 Sofnolime 温度迅速升高，而新鲜 Sofnolime 组的 Sofnolime 温度升高缓慢。