生物制剂与骨质流失
Biologicals and bone loss.
机构信息
Department of Rheumatology, Jan van Breemen Research Institute/Reade, Amsterdam, The Netherlands.
出版信息
Ther Adv Musculoskelet Dis. 2012 Aug;4(4):245-7. doi: 10.1177/1759720X12441275.
Abstract
Inflammatory joint diseases are associated with extra-articular side effects including bone involvement.There is an increased risk of osteoporotic fractures. The pathogeneses of local and generalized bone loss share a common pathway. Early and active rheumatoid arthritis is associated with longitudinal observed bone loss and fracture rate is of vertebral and nonvertebral fractures is doubled compared with matched healthy controls. Lowering disease activity with TNF inhibitors or is associated with stabilisation of bone mineral density by counteracting elevated bone resorption.
摘要
炎性关节病与包括骨骼受累在内的关节外副作用相关。存在骨质疏松性骨折风险增加。局部和全身性骨质流失的发病机制具有共同途径。早期和活跃的类风湿关节炎与纵向观察到的骨质流失有关，与匹配的健康对照组相比，椎体和非椎体骨折的发生率增加了一倍。使用 TNF 抑制剂降低疾病活动度与通过对抗骨吸收增加来稳定骨矿物质密度有关。
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