Baddi University of Emerging Sciences & Technology, Institute of Pharmacy & Emerging Sciences, Baddi, Himachal Pradesh, India.
Expert Opin Ther Pat. 2012 Sep;22(9):1019-32. doi: 10.1517/13543776.2012.714369. Epub 2012 Aug 4.
Vagina, due to its anatomical position and physiological characteristics is increasingly being explored as a site for drug delivery in recent years. This route coupled with bioadhesion phenomena has born fruitful results in delivering drugs both locally as well as systemically.
Bioadhesive vaginal drug delivery system has been used for the treatment of local diseases affecting the vagina like candidiasis, STD, vaginal dryness, and so on. Also, research has demonstrated that drugs can be successfully delivered to systemic circulation via vaginal mucosa for treatment of various diseases like migraine and osteoporosis. Besides, this vaginal route has also been used for uterine targeting of drugs. This review focuses on these recent innovations that have been patented in the area of bioadhesive vaginal drug delivery systems. The review also highlights certain physicochemical characteristics of bioadhesive polymers that affect drug delivery through this route.
An in-depth study of this review will give an insight into the potential areas that can be explored while designing a bioadhesive vaginal drug delivery system. Also, the in vitro and in vivo experimental results discussed in the review will help stimulate research in development and optimization of newer formulations.
近年来，由于解剖位置和生理特性，阴道越来越多地被探索作为药物传递的部位。这种途径结合生物粘附现象，在局部和全身递药方面都取得了丰硕的成果。
生物粘附阴道给药系统已用于治疗阴道局部疾病，如念珠菌病、性传播疾病、阴道干燥等。此外，研究表明，药物可以通过阴道黏膜成功递送到全身循环，用于治疗偏头痛和骨质疏松症等各种疾病。此外，这种阴道途径也被用于子宫靶向药物。本综述重点介绍了生物粘附阴道给药系统领域已获得专利的这些最新创新。综述还强调了影响通过该途径药物传递的某些生物粘附聚合物的物理化学特性。
深入研究本综述将深入了解在设计生物粘附阴道给药系统时可以探索的潜在领域。此外，综述中讨论的体外和体内实验结果将有助于激发对新型制剂的开发和优化的研究。
