Magner-Wróbel K, Jendryczko A, Drózdz M
Department of Chemistry and Biochemistry, Silesian Medical Academy, Katowice, Poland.
Cor Vasa. 1990;32(5):414-20.
The effect of long-term intake of hydralazine on myocardial lipid peroxidation (measured as formation of thiobarbituric acid-reactive substances and lipid peroxide concentrations), superoxide dismutase activity, and the protective action of vitamin A were studied in rats. Hydralazine was administered to rats for 6 months. Compared with the controls, the left ventricle of the hydralazine-treated animals had an increased thiobarbituric-acid reactive substance content and lipid hydroperoxide concentrations per g of wet tissue. Simultaneous administration of vitamin A prevented the changes in lipid peroxidation and significantly increased the superoxide dismutase activity compared with that in hydralazine-treated rats. The results seem to indicate that the increase of lipid peroxidation in rats treated with hydralazine is due not only to the stimulation, but also to the inhibition of superoxide dismutase activity.
研究了长期摄入肼屈嗪对大鼠心肌脂质过氧化作用（以硫代巴比妥酸反应性物质的形成和脂质过氧化物浓度衡量）、超氧化物歧化酶活性以及维生素A保护作用的影响。给大鼠服用肼屈嗪6个月。与对照组相比，服用肼屈嗪的动物左心室每克湿组织中硫代巴比妥酸反应性物质含量和脂质氢过氧化物浓度增加。同时给予维生素A可防止脂质过氧化的变化，并与服用肼屈嗪的大鼠相比显著提高超氧化物歧化酶活性。结果似乎表明，服用肼屈嗪的大鼠脂质过氧化增加不仅是由于超氧化物歧化酶活性受到刺激，还由于其受到抑制。
