同源域蛋白 HOXB9 调节生长和血管生成因子的表达，促进体外肿瘤生长，并且在乳腺癌组织中过度表达。
Homeodomain-containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue.
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Arlington, TX, USA.
出版信息
FEBS J. 2012 Oct;279(19):3715-3726. doi: 10.1111/j.1742-4658.2012.08733.x. Epub 2012 Aug 31.
Abstract
HOXB9 is a homeobox-containing gene and is critical for the development of mammary gland and sternum. HOXB9 is also regulated by estrogen and is critical for angiogenesis. We investigated the biochemical roles of HOXB9 and its homeodomain in cell-cycle progression and tumorigenesis. Our studies demonstrated that HOXB9 is overexpressed in breast cancer tissue. HOXB9 overexpression stimulated 3D formation in soft agar assay. HOXB9 binds to the promoters of various tumor growth and angiogenic factors and regulates their expression. The homeodomain of HOXB9 plays crucial roles in transcriptional regulation of tumor growth factors and also in 3D colony formation, indicating crucial roles of the HOXB9 homeodomain in tumorigenesis. Overall, we demonstrated that HOXB9 is a critical regulator of tumor growth factors and is associated with tumorigenesis.
摘要
HOXB9 是一个含有同源盒的基因，对乳腺和胸骨的发育至关重要。HOXB9 也受雌激素调控，对血管生成至关重要。我们研究了 HOXB9 及其同源域在细胞周期进程和肿瘤发生中的生化作用。我们的研究表明，HOXB9 在乳腺癌组织中过度表达。HOXB9 过表达刺激软琼脂测定中的 3D 形成。HOXB9 与各种肿瘤生长和血管生成因子的启动子结合，并调节它们的表达。HOXB9 的同源域在肿瘤生长因子的转录调控中发挥关键作用，也在 3D 集落形成中发挥关键作用，表明 HOXB9 同源域在肿瘤发生中起着关键作用。总的来说，我们证明了 HOXB9 是肿瘤生长因子的关键调节剂，与肿瘤发生有关。
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本文引用的文献
1
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Cardiovasc Res. 2012 Mar 1;93(3):516-24. doi: 10.1093/cvr/cvr352. Epub 2011 Dec 26.
2
HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.HOXC10 在乳腺癌中过表达，并通过组蛋白甲基转移酶 MLL3 和 MLL4 的参与，受雌激素转录调控。
J Mol Endocrinol. 2012 Jan 25;48(1):61-75. doi: 10.1530/JME-11-0078. Print 2012 Feb.
3
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.Homeobox B9 通过加速 DNA 损伤反应诱导上皮-间充质转化相关的放射抵抗。
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2760-5. doi: 10.1073/pnas.1018867108. Epub 2011 Sep 19.
4
Gene expression and hypoxia in breast cancer.乳腺癌中的基因表达和缺氧。
Genome Med. 2011 Aug 26;3(8):55. doi: 10.1186/gm271.
5
HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.HOXC6 通过在雌激素环境中协调 MLL 组蛋白甲基转移酶和雌激素受体进行转录调控。
J Mol Biol. 2011 Aug 12;411(2):334-49. doi: 10.1016/j.jmb.2011.05.050. Epub 2011 Jun 12.
6
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Indian J Med Paediatr Oncol. 2010 Oct;31(4):132-6. doi: 10.4103/0971-5851.76197.
7
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8
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9
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PLoS One. 2010 May 12;5(5):e10600. doi: 10.1371/journal.pone.0010600.
10
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FEBS J. 2010 Apr;277(8):1790-804. doi: 10.1111/j.1742-4658.2010.07606.x. Epub 2010 Mar 4.
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