Sapienza University of Rome, Dept. of Experimental Medicine, Viale del Policlinico 155, 00161 Rome, Italy.
Best Pract Res Clin Endocrinol Metab. 2012 Aug;26(4):539-50. doi: 10.1016/j.beem.2011.12.005. Epub 2012 May 22.
Male hypogonadism is traditionally defined as the inadequate production of testosterone and impaired spermatozoa generation in the presence of elevated or reduced levels of gonadotropins. A more frequent measurement of testosterone levels and the development of highly sensitive and specific assays have led to the detection of less clinically evident gonadal dysfunction, in which small biochemical alterations may or may not be accompanied by signs and symptoms. This condition is called "compensated" or "subclinical" hypogonadism. To determine whether subclinical hypogonadism is a paraphysiological state, a clinical condition in itself, or a precursor to overt hypogonadism, we carried out a literature review with the aim of establishing a practical approach to subclinical hypogonadism.
男性性腺功能减退症传统上被定义为在升高或降低的性腺激素水平存在下，睾丸酮产生不足和精子生成受损。更频繁地测量睾丸酮水平以及高度敏感和特异性检测方法的发展，导致检测到较少的临床明显性腺功能障碍，其中小的生化改变可能伴有或不伴有体征和症状。这种情况被称为“代偿性”或“亚临床”性腺功能减退症。为了确定亚临床性腺功能减退症是一种副生理状态、一种临床情况本身，还是明显性腺功能减退症的前兆，我们进行了文献回顾，旨在制定亚临床性腺功能减退症的实用方法。
