West A K, Stallings R, Hildebrand C E, Chiu R, Karin M, Richards R I
Department of Biochemistry, University of Tasmania, Australia.
Genomics. 1990 Nov;8(3):513-8. doi: 10.1016/0888-7543(90)90038-v.
The functional human metallothionein (MT) genes are located on chromosome 16q13. We have physically mapped the functional human MT locus by isolation and restriction digest mapping of cloned DNA. The mapped region contains all sequences on chromosome 16 that hybridize to metallothionein gene probes and comprises 14 tightly linked MT genes, 6 of which have not been previously described. This analysis defines the genetic limits of metallothionein functional diversity in the human genome.
功能性人类金属硫蛋白（MT）基因位于16号染色体的16q13区域。我们通过对克隆DNA进行分离和限制性酶切图谱分析，对功能性人类MT基因座进行了物理定位。定位区域包含16号染色体上所有与金属硫蛋白基因探针杂交的序列，由14个紧密连锁的MT基因组成，其中6个基因此前未被描述。该分析确定了人类基因组中金属硫蛋白功能多样性的遗传界限。
