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[盆腔癌性神经病变:临床、放射学及治疗意义]

[Pelvic carcinomatous neuropathy: clinical, radiologic, therapeutic implications].

作者信息

Russi E G, Gaeta M, Pergolizzi S, d'Aquino A, Mesiti M, Raffaele M, Di Carlo M, Delia P, Romeo F

机构信息

Istituto di Clinica Oncologica e di Ricerca sui Tumori, Università degli Studi di Messina.

出版信息

G Ital Oncol. 1990 Jul-Sep;10(3):77-84.

PMID:2286396
Abstract

Carcinomatous involvement of the pelvic nerves (Pelvic Carcinomatous Neuropathy-PCN-) causes disabling sensorial and motor disturbances of the lower extremities. Recurrent rectal carcinomas are the most common cause of PCN because surgical obliteration of the perirectal fascia. In 31 cases of PCN Authors describe the types of the neoplasm and the sites of involvement of the pelvic nerves evaluating clinical syndromes and Computed Tomography. The results of radiotherapy (doses between 36-56 Gy) in 14 cases of PCN by recurrent rectal cancer are also reported. Although the survival of such patients is poor, radiotherapy has obtained a good palliative result in 50% of them. Personalization of radiation treatment planning is advisable in order to avoid acute side-effects.

摘要

盆腔神经的癌性侵犯(盆腔癌性神经病变-PCN-)会导致下肢出现致残性的感觉和运动障碍。复发性直肠癌是PCN最常见的病因,这是由于直肠周围筋膜的手术闭塞所致。在31例PCN病例中,作者通过评估临床综合征和计算机断层扫描描述了肿瘤的类型以及盆腔神经的受累部位。还报告了14例复发性直肠癌所致PCN患者的放疗结果(剂量在36 - 56 Gy之间)。尽管此类患者的生存率较低,但放疗在其中50%的患者中取得了良好的姑息效果。为避免急性副作用,建议对放射治疗计划进行个性化定制。

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