Mayo Medical School, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
J Neurointerv Surg. 2013 Sep 1;5(5):483-6. doi: 10.1136/neurintsurg-2012-010468. Epub 2012 Aug 4.
Idiopathic intracranial hypertension (IIH) is characterized by headache, papilledema, visual field changes and tinnitus with elevated cerebral spinal fluid opening pressures on lumbar puncture. Left untreated, this condition can lead to permanent visual loss. Previous treatment modalities include medical management, therapeutic lumbar puncture and optic nerve sheath fenestration. They have proved to be effective but carry high rates of symptom recurrence or procedural complications. Focal dural venous sinus stenoses have been identified in many patients with IIH, leading to development of treatment through venous sinus angioplasty and stenting. A review of the literature was performed which identified patients with IIH treated with venous sinus stenting. The procedural data and outcomes are presented. A total of 143 patients with IIH (87% women, mean age 41.4 years, mean body mass index 31.6 kg/m(2)) treated with venous sinus stenting were included in the analysis. Symptoms at initial presentation included headache (90%), papilledema (89%), visual changes (62%) and pulsatile tinnitus (48%). There was a technical success rate of 99% for the stent placement procedure with a total of nine complications (6%). At follow-up (mean 22.3 months), 88% of patients experienced improvement in headache, 97% demonstrated improvement or resolution of papilledema, 87% experienced improvement or resolution of visual symptoms and 93% had resolution of pulsatile tinnitus. In patients with IIH with focal venous sinus stenosis, endovascular stent placement across the stenotic sinus region represents an effective treatment strategy with a high technical success rate and decreased rate of complications compared with treatment modalities currently used.
特发性颅内高压(IIH)的特征是头痛、视乳头水肿、视野改变和耳鸣,腰椎穿刺时脑脊髓液开放压力升高。如果不治疗,这种情况可能导致永久性视力丧失。以前的治疗方法包括药物治疗、治疗性腰椎穿刺和视神经鞘开窗术。这些方法已被证明是有效的,但复发率或程序并发症很高。许多 IIH 患者存在局灶性硬脑膜静脉窦狭窄,导致通过静脉窦血管成形术和支架置入来进行治疗。对已发表的文献进行了回顾,确定了接受静脉窦支架置入术治疗的 IIH 患者。介绍了程序数据和结果。共纳入 143 例 IIH 患者(87%为女性,平均年龄 41.4 岁,平均体重指数 31.6kg/m2)接受静脉窦支架置入术治疗。初次就诊时的症状包括头痛(90%)、视乳头水肿(89%)、视力改变(62%)和搏动性耳鸣(48%)。支架放置术的技术成功率为 99%,共发生 9 例并发症(6%)。随访(平均 22.3 个月)时,88%的患者头痛改善,97%的患者视乳头水肿改善或消退,87%的患者视力症状改善或消退,93%的患者搏动性耳鸣消退。对于有局灶性静脉窦狭窄的 IIH 患者,血管内支架置入术横跨狭窄的窦区是一种有效的治疗策略,与目前使用的治疗方法相比,具有更高的技术成功率和更低的并发症发生率。