Walkden Deborah, Badami Krishna
New Zealand Blood Service, 87 Riccarton Road, Christchurch, New Zealand.
N Z Med J. 2012 Jul 29;125(1358):29-34.
To determine venesection patterns in hereditary haemochromatosis (HC) patients in Christchurch, New Zealand, their contribution to the blood supply, and reasons for deferral.
Review of clinical records of 412 HC patients venesected by the NZ Blood Service at least once during 2009.
Of 275 males and 137 females, 384 had been tested for HFE gene mutations--76% were C282Y homozygotes, 12.8%, C282Y/H63D compound heterozygous, 8.6%, either H63D homozygotes, C282Y heterozygotes or H63D heterozygotes. Small numbers had no detectable mutations, were not iron overloaded but had been venesected for isolated hyperferritiniaemia. 53% were donors. C282Y homozygotes required significantly more venesections than patients of other genotypes. Eligible HC patients donated 3 units/donor/year compared to 1.63/person/year by healthy donors (p<0.001). HC patients contributed 3.4% of whole blood collections in 2009. There were 212 permanent or temporary donation deferrals--common reasons were abnormal liver functions, chronic or malignant disease, or immigration from vCJD risk countries.
HC donors donate at nearly twice the rate of healthy donors but contribute only a small amount to the blood pool. Revision of selection criteria may increase this contribution without compromising blood safety.
确定新西兰克赖斯特彻奇市遗传性血色素沉着症（HC）患者的静脉切开模式、他们对血液供应的贡献以及延期献血的原因。
回顾2009年期间至少接受过一次新西兰血液服务机构静脉切开术的412例HC患者的临床记录。
275名男性和137名女性中，384人接受了HFE基因突变检测——76%为C282Y纯合子，12.8%为C282Y/H63D复合杂合子，8.6%为H63D纯合子、C282Y杂合子或H63D杂合子。少数患者未检测到突变，没有铁过载，但因孤立性高铁蛋白血症接受了静脉切开术。53%为献血者。C282Y纯合子比其他基因型患者需要更多的静脉切开术。符合条件的HC患者每人每年献血3单位，而健康献血者每人每年献血1.63单位（p<0.001）。2009年，HC患者贡献了3.4%的全血采集量。有212例永久性或临时性献血延期——常见原因是肝功能异常、慢性或恶性疾病，或来自克雅氏病风险国家的移民。
HC献血者的献血率几乎是健康献血者的两倍，但对血库的贡献仅占一小部分。修订选择标准可能会增加这一贡献，同时又不影响血液安全。
