Sakakura Kenichi, Ako Junya, Wada Hiroshi, Naito Ryo, Arao Kenshiro, Funayama Hiroshi, Kubo Norifumi, Momomura Shin-ichi
Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Amanuma 1-847, Omiya, Saitama, 330-8503 Japan.
J Invasive Cardiol. 2012 Aug;24(8):379-84.
The purpose of this study was to investigate the association between beta-blocker use and slow flow during rotational atherectomy (RA).
RA is often performed as part of percutaneous coronary interventions for the treatment of calcified lesions; however, the procedure can be complicated by slow flow. Previous reports suggested that the use of beta-blockers was associated with slow flow during RA.
A total of 186 patients who received RA were included, and 87 patients were on beta-blockers. The occurrence of slow flow was compared between the beta-blocker group (n = 87) and the non-beta-blocker group (n = 99). Multivariate logistic regression analysis was performed to investigate whether the use of beta-blockers was associated with slow flow.
The occurrence of slow flow was not different between the beta-blocker group (29.9%) and the non-beta-blocker group (24.2%; P=.39). The use of beta-blockers was not significantly associated with slow flow (odds ratio, 0.75; 95% confidence interval, 0.34-1.68; P=.49) after controlling for all potential confounding factors.
There was no definitive association between slow flow and the use of beta-blockers during RA. There is no need to discontinue beta-blockers in patients receiving RA.
本研究旨在探讨在旋磨术（RA）期间使用β受体阻滞剂与慢血流之间的关联。
RA常作为经皮冠状动脉介入治疗钙化病变的一部分进行；然而，该手术可能会因慢血流而变得复杂。先前的报告表明，在RA期间使用β受体阻滞剂与慢血流有关。
共纳入186例接受RA的患者，其中87例患者正在使用β受体阻滞剂。比较β受体阻滞剂组（n = 87）和非β受体阻滞剂组（n = 99）中慢血流的发生率。进行多因素逻辑回归分析以研究使用β受体阻滞剂是否与慢血流有关。
β受体阻滞剂组（29.9%）和非β受体阻滞剂组（24.2%；P = 0.39）中慢血流的发生率没有差异。在控制所有潜在混杂因素后，使用β受体阻滞剂与慢血流没有显著关联（比值比，0.75；95%置信区间，0.34 - 1.68；P = 0.49）。
在RA期间，慢血流与使用β受体阻滞剂之间没有明确的关联。接受RA的患者无需停用β受体阻滞剂。
