果蝇卵子发生中的 mRNA 定位和翻译调控。
mRNA localization and translational control in Drosophila oogenesis.
机构信息
Department of Biology, Bellini Life Sciences Building, McGill University, Montréal, Québec H3G 0B1, Canada.
出版信息
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10):a012294. doi: 10.1101/cshperspect.a012294.
Abstract
Localization of an mRNA species to a particular subcellular region can complement translational control mechanisms to produce a restricted spatial distribution of the protein it encodes. mRNA localization has been studied most in asymmetric cells such as budding yeast, early embryos, and neurons, but the process is likely to be more widespread. This article reviews the current state of knowledge about the mechanisms of mRNA localization and its functions in early embryonic development, focusing on Drosophila where the relevant knowledge is most advanced. Links between mRNA localization and translational control mechanisms also are examined.
摘要
mRNA 物种定位于特定的亚细胞区域可以补充翻译控制机制，从而产生其所编码的蛋白质的受限空间分布。mRNA 定位在不对称细胞中研究最多，如芽殖酵母、早期胚胎和神经元，但这个过程可能更为广泛。本文综述了 mRNA 定位的机制及其在早期胚胎发育中的功能的最新知识，重点介绍了相关知识最先进的果蝇。还检查了 mRNA 定位与翻译控制机制之间的联系。
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