Siiteri P K
Arthritis Rheum. 1979 Nov;22(11):1284-94. doi: 10.1002/art.1780221117.
The mechanisms of the production of estrogens and androgens in women and men are reviewed. Extraglandular estrogen formation from circulating androgens is the principal source of estrogen in men and postmenopausal women. The amount of estrogen formed is dependent upon precursor availability and metabolic factors, such as obesity and hepatic disease. Both androgens and estrogens in the circulation of humans are bound to sex hormone binding globulin which limits their availability to target cell receptors.
本文综述了女性和男性体内雌激素和雄激素的产生机制。循环雄激素在外腺体外转化为雌激素是男性和绝经后女性雌激素的主要来源。雌激素的生成量取决于前体物质的可利用性以及代谢因素，如肥胖和肝脏疾病。人体内循环中的雄激素和雌激素均与性激素结合球蛋白结合，这限制了它们与靶细胞受体的结合。
