Cardiovascular Genetic Program, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA.
Trends Cardiovasc Med. 2012 Feb;22(2):35-9. doi: 10.1016/j.tcm.2012.06.008. Epub 2012 Aug 4.
Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na(+) channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate.
最近的研究表明，氟卡尼可能是治疗儿茶酚胺多形性室性心动过速患者致命性心律失常的有效方法。已经提出了几种假说来解释氟卡尼的抗心律失常机制，包括钠离子通道阻断和对兰尼碱受体的直接抑制作用。本文综述了该领域的现有文献，并总结了目前争议的要点。
