Regulating the Regulator: Phosphorylation of PKC θ in T Cells.
作者信息
Freeley Michael, Long Aideen
机构信息
Clinical Medicine, Trinity College Dublin Dublin, Ireland.
出版信息
Front Immunol. 2012 Aug 1;3:227. doi: 10.3389/fimmu.2012.00227. eCollection 2012.
Abstract
摘要
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本文引用的文献
1
Regulation of PKC-θ function by phosphorylation in T cell receptor signaling.PKC-θ 功能受 T 细胞受体信号转导中磷酸化的调节。
Front Immunol. 2012 Jul 11;3:197. doi: 10.3389/fimmu.2012.00197. eCollection 2012.
2
PKCθ: a new target for selective immunosuppression.蛋白激酶Cθ：选择性免疫抑制的新靶点。
Expert Rev Clin Immunol. 2012 Mar;8(3):205-8. doi: 10.1586/eci.12.8.
3
PKC-θ function at the immunological synapse: prospects for therapeutic targeting.PKC-θ 在免疫突触中的作用：治疗靶点的前景。
Trends Immunol. 2011 Aug;32(8):358-63. doi: 10.1016/j.it.2011.04.007. Epub 2011 Jul 4.
4
A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.一连串的蛋白激酶 C 同工酶促进 T 细胞骨架极化。
Nat Immunol. 2011 May 22;12(7):647-54. doi: 10.1038/ni.2033.
5
Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.染色质相关蛋白激酶 C-θ 调节人 T 淋巴细胞中的诱导型基因表达程序和 microRNAs。
Mol Cell. 2011 Mar 18;41(6):704-19. doi: 10.1016/j.molcel.2011.02.030.
6
Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites.蛋白激酶 C 功能的调节通过保守和非保守位点的磷酸化。
Cell Signal. 2011 May;23(5):753-62. doi: 10.1016/j.cellsig.2010.10.013. Epub 2010 Oct 12.
7
Protein kinase C-theta mediates negative feedback on regulatory T cell function.蛋白激酶 C-θ负反馈调节调节性 T 细胞功能。
Science. 2010 Apr 16;328(5976):372-6. doi: 10.1126/science.1186068. Epub 2010 Mar 25.
8
PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.蛋白激酶C-θ通过将Cbl-b靶向泛素化和降解来调节T细胞反应的强度。
Sci Signal. 2009 Jun 23;2(76):ra30. doi: 10.1126/scisignal.2000046.
9
Loss of protein kinase C theta, Bcl10, or Malt1 selectively impairs proliferation and NF-kappa B activation in the CD4+ T cell subset.蛋白激酶Cθ、Bcl10或Malt1的缺失选择性地损害CD4 + T细胞亚群中的增殖和NF-κB激活。
J Immunol. 2008 Nov 1;181(9):6244-54. doi: 10.4049/jimmunol.181.9.6244.
10
PKC-theta selectively controls the adhesion-stimulating molecule Rap1.蛋白激酶C-θ选择性地调控黏附刺激分子Rap1。
Blood. 2008 Dec 1;112(12):4617-27. doi: 10.1182/blood-2007-11-121111. Epub 2008 Sep 16.
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