非典型股骨骨折：证据回顾及其对临床实践的影响。
Atypical femur fractures: a review of the evidence and its implication to clinical practice.
出版信息
Ther Adv Musculoskelet Dis. 2011 Dec;3(6):301-14. doi: 10.1177/1759720X11416270.
Abstract
Whilst bisphosphonates are an established modality in the treatment of osteoporosis, there have been increasing concerns regarding the risk of an unusual form of femur fracture amongst patients receiving bisphosphonates for prolonged periods. These fractures, referred to as 'atypical', have been characterized by a number of clinical and radiographic features that distinguish them from 'typical' osteoporotic fractures. The evidence base is currently split between a large number of case series demonstrating an association between the occurrence of atypical fractures and bisphosphonate use and several population-based studies that do not confirm such an association. Hence, a degree of uncertainty surrounds this important issue. In this review, we examine the emerging evidence on atypical femur fractures, assess hypotheses on their biomechanical evolution and discuss the wider clinical implications of this phenomenon.
摘要
虽然双膦酸盐是治疗骨质疏松症的一种既定方式，但人们越来越关注接受双膦酸盐治疗的患者中出现一种不寻常的股骨骨折形式的风险。这些骨折被称为“非典型性”，具有许多临床和影像学特征，可以将其与“典型”骨质疏松性骨折区分开来。目前，证据基础在大量病例系列研究之间存在分歧，这些研究表明非典型骨折的发生与双膦酸盐的使用之间存在关联，而一些基于人群的研究则不确认这种关联。因此，围绕这个重要问题存在一定程度的不确定性。在这篇综述中，我们检查了非典型股骨骨折的新出现证据，评估了关于其生物力学演变的假说，并讨论了这一现象的更广泛的临床意义。
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