Szabó Andrea, Szabó Barnabas, Balogh Emese, Zelkó Romána, Antal István
DocMorris Apotheke Neustadt, Mainz, Németország, Kreyssigstr. 19. D-55118.
Acta Pharm Hung. 2012;82(2):69-74.
Beside the many advantages of intraarticular formulations (e.g., the systemic side effects are kept away), there is a big drawback. During the injections, there is the risk for infection therefore the number of injections in a year should be reduced. Also a long-term drug exposure should be achieved with an injection, and if it is possible, a combination of active ingredients should be used. At present there are only formulations with hyaluronic acid or glucocorticoid on the market. One of these formulations, a liposomal preparation, is of sustained drug release. Many different active ingredients could have a long-term drug exposure with carrier systems like micro- and nanoparticles, liposomes, hydrogels and physically activated delivery systems (thermoresponsive or magnetically modulated). The present paper gives an overview about these carrier systems, the novel scientific results and the aim of the future researches, as well.
除了关节内制剂的诸多优点（例如，可避免全身副作用）外，还有一个很大的缺点。在注射过程中，存在感染风险，因此每年的注射次数应减少。此外，一次注射应实现长期药物暴露，并且如果可能的话，应使用活性成分的组合。目前市场上只有透明质酸或糖皮质激素制剂。其中一种制剂，即脂质体制剂，具有药物缓释作用。许多不同的活性成分可以通过微纳米颗粒、脂质体、水凝胶和物理激活递送系统（热响应或磁调制）等载体系统实现长期药物暴露。本文还概述了这些载体系统、新的科学成果以及未来研究的目标。
