10%吡虫啉和 1%莫昔克丁合剂对非洲刺猬（Atelerix albiventris）的 Caparinia tripilis 的疗效。
Efficacy of a combination of 10% imidacloprid and 1% moxidectin against Caparinia tripilis in African pygmy hedgehog (Atelerix albiventris).
机构信息
Department of Parasitology, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea.
出版信息
Parasit Vectors. 2012 Aug 7;5:158. doi: 10.1186/1756-3305-5-158.
BACKGROUND
The efficacy and safety of a combination formulation of 10% imidacloprid + 1.0% moxidectin spot-on (Advocate® for Cats, Bayer Animal Health GmbH, Leverkusen, Germany) was tested in 40 African pygmy hedgehogs (Atelerix albiventris) naturally infested with Caparinia tripilis.
METHODS
The optimal dosage level of the combination for hedgehogs was determined by assigning 20 hedgehogs into three treatment groups (0.1, 0.4 and 1.6 ml/Kg b.w.), and one untreated control group of 5 hedgehogs each. Twenty naturally infested hedgehogs were then randomly assigned to either treatment or control group with 10 animals each, and the number of live mites was counted from 13 body regions on day 0, 3, 9, 16, and 30 after single treatment at the dosage level of 0.1 ml/Kg.
RESULTS
Before the chemotherapy, the highest density of mite was observed in external ear canals followed by the dorsal and the lowest in the ventral regions of the body surface. The dosage level of 0.1 ml/Kg, which corresponded to the recommended dosage level for cats, containing 10 mg imidacloprid and 1 mg moxidectin was also the optimal dosage level for hedgehogs. No hedgehogs in the treatment group showed live mites from day 3 post treatment. Side effects such as ataxia, depression, nausea, and weight fluctuation were not observed during the whole period of study.
CONCLUSIONS
This report suggests that a combination formulation of 0.1 ml/Kg of 10% imidacloprid + 1% moxidectin spot-on for cats is also useful for the control of Caparinia tripilis infestation in hedgehogs.
背景
本研究旨在评估 10%吡虫啉+1.0%莫昔克丁滴剂（拜耳动物保健有限公司，德国勒沃库森）在自然感染 Caparinia tripilis 的 40 只非洲刺猬（Atelerix albiventris）中的疗效和安全性。
方法
通过将 20 只刺猬分配到 3 个治疗组（0.1、0.4 和 1.6 ml/Kg b.w.）和 1 个未治疗对照组（每组 5 只），确定该组合对刺猬的最佳剂量水平。然后，将 20 只自然感染的刺猬随机分配到治疗组或对照组，每组 10 只，在 0.1 ml/Kg 剂量水平下，在第 0、3、9、16 和 30 天对 13 个体表部位的活螨数量进行计数。
结果
在化疗前，耳垢中的螨虫密度最高，其次是背部，腹部最低。0.1 ml/Kg 的剂量水平，对应于猫的推荐剂量水平，含有 10 mg 吡虫啉和 1 mg 莫昔克丁，也是刺猬的最佳剂量水平。治疗组的刺猬从第 3 天开始没有发现活螨。在整个研究期间，未观察到共济失调、抑郁、恶心和体重波动等副作用。
结论
本报告表明，猫用 10%吡虫啉+1%莫昔克丁滴剂 0.1 ml/Kg 的组合制剂也可有效控制刺猬的 Caparinia tripilis 感染。
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