Makimura S, Usui M
Department of Veterinary Medicine, Faculty of Agriculture, Miyazaki University, Japan.
Nihon Juigaku Zasshi. 1990 Dec;52(6):1245-50. doi: 10.1292/jvms1939.52.1245.
The correlation between haptoglobin (Hp) and mucoprotein or sialic acid in sera from diseased cattle was examined to evaluate the clinical application of serum Hp. First, the ranges of mucoprotein, sialic acid and hemoglobin binding capacity (HbBC) of 46 healthy cattle were determined. Then, levels of these reactants in 35 cattle suffering from various diseases were measured. The frequency of the abnormal values was 94.3% in mucoprotein, 45.7% in sialic acid and 82.9% in HbBC in diseased cattle. There was a significant correlation between mucoprotein and sialic acid, and between HbBC and mucoprotein or sialic acid. Some correlation between mucoprotein and neutrophils or alpha-globulin was also observed. In spite of high levels of mucoprotein and sialic acid, lower HbBC than expected levels were often observed in inflammatory disorders. Such cases might be complicated with some hemolytic disorders such as piroplasmosis. Determining serum HbBC together with other acute phase reactants might be useful for evaluating inflammatory diseases complicated with hemolytic disorders.
检测患病牛血清中触珠蛋白（Hp）与粘蛋白或唾液酸之间的相关性，以评估血清Hp的临床应用价值。首先，测定了46头健康牛的粘蛋白、唾液酸和血红蛋白结合能力（HbBC）范围。然后，检测了35头患有各种疾病的牛的这些反应物水平。患病牛中粘蛋白异常值的频率为94.3%，唾液酸为45.7%，HbBC为82.9%。粘蛋白与唾液酸之间、HbBC与粘蛋白或唾液酸之间存在显著相关性。还观察到粘蛋白与中性粒细胞或α-球蛋白之间存在一定相关性。尽管粘蛋白和唾液酸水平较高，但在炎症性疾病中常观察到HbBC低于预期水平。此类病例可能并发一些溶血性疾病，如梨形虫病。同时测定血清HbBC和其他急性期反应物可能有助于评估并发溶血性疾病的炎症性疾病。
