Hisada M, Okamoto S, Nakajima H, Nogawa S, Shigeta Y, Kawamura K
Department of Internal Medicine, Ise Keio Hospital, Japan.
Keio J Med. 1990 Dec;39(4):261-4. doi: 10.2302/kjm.39.261.
We report a 69 year-old female with sarcoidosis who developed chronic thrombocytopenia, a rare complication of this disorder. Histologically normal bone marrow with increased number of megakaryocytes and high level of PAIgG strongly suggest the immune destruction of platelets as the cause of thrombocytopenia. In addition to thrombocytopenia, this case is also distinctive in its clinical manifestation. The patient developed several infrequent manifestations of sarcoidosis including complete AV block, uveitis, skin eruptions and middle lobe syndrome, but, did not have an intrathoracic adenopathy, the commonest manifestation of this disease.
我们报告了一名69岁的结节病女性患者，她出现了慢性血小板减少症，这是该疾病一种罕见的并发症。组织学上正常的骨髓中巨核细胞数量增加以及PAIgG水平升高，强烈提示血小板的免疫破坏是血小板减少症的病因。除血小板减少症外，该病例在临床表现上也很独特。患者出现了结节病的几种罕见表现，包括完全性房室传导阻滞、葡萄膜炎、皮疹和中叶综合征，但没有该疾病最常见的胸内淋巴结肿大表现。
