Glasgow Caledonian University, Vision Sciences, Department of Life Sciences, Glasgow, United Kingdom.
Invest Ophthalmol Vis Sci. 2012 Aug 27;53(9):5881-9. doi: 10.1167/iovs.12-10399.
The aim of our study was to investigate the correlation between neural and hemodynamic responses to stereoscopic stimuli recorded over visual cortex.
Test stimuli consisted of a static checkerboard (checks) and dichoptic static random dot (RD) presentations with no binocular disparity (ZD) or with horizontal disparity (HD). Hemodynamic responses were recorded from right and left occipital sites using functional near-infrared spectroscopy (fNIRS). Visual evoked potentials (VEPs) were recorded over three occipital sites to the onset of the same stimuli.
Early components, N1 and P2, were sensitive to HD, suggesting that an enhanced N1-reduced P2 complex could be an indicator of binocular disparity and stereopsis. VEPs to checks and ZD stimulation were similar. fNIRS recordings showed changes in hemodynamic activation from baseline levels in response to all stimuli. In general, HD elicited a larger vascular response than ZD. Oxyhemoglobin concentration (HbO) was correlated with the VEP amplitude during the checks and HD presentations.
We report an association between neural and hemodynamic activation in response to checks and HD. In addition, the results suggested that N1-P2 complex in the VEP could be a neural marker for stereopsis and fNIRS demonstrated differences in HbO. Specifically, checks and HD elicited larger hemodynamic responses than random dot patterns without binocular disparity.
我们的研究旨在探讨视觉皮层记录的立体刺激的神经和血液动力学反应之间的相关性。
测试刺激由静态棋盘（检查）和双静态随机点（RD）呈现组成，没有双目视差（ZD）或具有水平视差（HD）。使用功能近红外光谱（fNIRS）记录来自右侧和左侧枕部的血液动力学反应。视觉诱发电位（VEPs）在三个枕部记录到相同刺激的起始。
早期成分 N1 和 P2 对 HD 敏感，表明增强的 N1-减少的 P2 复合物可能是双目视差和立体视的指标。检查和 ZD 刺激的 VEP 相似。fNIRS 记录显示，所有刺激均引起基线水平的血液动力学激活变化。一般来说，HD 引起的血管反应大于 ZD。氧合血红蛋白浓度（HbO）与检查和 HD 呈现期间的 VEP 幅度相关。
我们报告了对检查和 HD 的神经和血液动力学激活之间的关联。此外，结果表明，VEP 中的 N1-P2 复合物可能是立体视的神经标志物，fNIRS 证明了 HbO 的差异。具体而言，检查和 HD 引起的血液动力学反应大于没有双目视差的随机点模式。
