van der Meulen Jacques
Dutch Craniofacial Unit, Department of Plastic, Reconstructive and Hand Surgery, Sophia Children's Hospital, Erasmus Medical Center, Dr Molewaterplein 60, 3015GJ, Rotterdam, The Netherlands.
Childs Nerv Syst. 2012 Sep;28(9):1359-67. doi: 10.1007/s00381-012-1803-z. Epub 2012 Aug 8.
Premature closure of the metopic suture results in a growth restriction of the frontal bones, which leads to a skull malformation known as trigonocephaly. Over the course of recent decades, its incidence has been rising, currently making it the second most common type of craniosynostosis. Treatment consists of a cranioplasty, usually preformed before the age of 1 year. Metopic synostosis is linked with an increased level of neurodevelopmental delays. Theories on the etiology of these delays range from a reduced volume of the anterior cranial fossa to intrinsic malformations of the brain. This paper aims to provide an overview of this entity by giving an update on the epidemiology, etiology, evolution of treatment, follow-up, and neurodevelopment of metopic synostosis.
额缝过早闭合会导致额骨生长受限，进而引发一种称为三角头畸形的颅骨畸形。在最近几十年里，其发病率一直在上升，目前已成为第二常见的颅缝早闭类型。治疗方法包括颅骨成形术，通常在1岁之前进行。额缝早闭与神经发育延迟水平的升高有关。关于这些延迟病因的理论范围从颅前窝容积减少到大脑的内在畸形。本文旨在通过介绍额缝早闭的流行病学、病因、治疗进展、随访情况和神经发育等方面的最新信息，对这一病症进行概述。
