Bobylev A G, Shpagina M D, Bobyleva L G, Okuneva A D, Piotrovskiĭ L B, Podlubnaia Z A
Biofizika. 2012 May-Jun;57(3):416-21.
A comparative estimation of the ability of complexes of fullerene C60 with polyvinylpyrrolidone and fullerene C60 derivatives (the sodium salt of the polycarboxylic derivative of fullerene C60, sodium fullerenolate), has been carried out. The fullerenes destroyed amyloid fibrils of the Abeta(1-42) peptide of the brain and the muscle X-protein. A study of the effect of fullerenes on muscle actin showed that complexes of fullerene C60 with polyvinylpyrrolidone and sodium fullerenolate did not prevent the filament formation of actin, nor did they destroy its filaments in vitro. Conversely, sodium salt of the polycarboxylic derivative of fullerene C60 destroyed actin filaments and prevented their formation. It was concluded that sodium fullerenolate and complexes of fullerene C60 with polyvinylpyrrolidone are the most effective antiamyloid compounds among the fullerenes examined.
对富勒烯C60与聚乙烯吡咯烷酮的复合物以及富勒烯C60衍生物（富勒烯C60多元羧酸衍生物的钠盐，即富勒烯醇钠）的能力进行了比较评估。富勒烯破坏了大脑中β-淀粉样蛋白（1-42）肽和肌肉X蛋白的淀粉样纤维。对富勒烯对肌肉肌动蛋白影响的研究表明，富勒烯C60与聚乙烯吡咯烷酮的复合物以及富勒烯醇钠在体外既不阻止肌动蛋白的丝形成，也不破坏其丝。相反，富勒烯C60多元羧酸衍生物的钠盐破坏了肌动蛋白丝并阻止其形成。得出的结论是，在所研究的富勒烯中，富勒烯醇钠和富勒烯C60与聚乙烯吡咯烷酮的复合物是最有效的抗淀粉样化合物。
