Bobylëv A G, Okuneva A D, Bobylëva L G, Fadeeva I S, Fadeev R S, Salmov N N, Poddubnaia Z A
Biofizika. 2012 Sep-Oct;57(5):746-50.
We investigated the cytotoxicity of the fullerene C60 derivatives. We showed that complexes of C60 fullerene with polyvinylpyrrolidone (m.w. of polyvinylpyrrolidone 10000 and 25000), C60-NO2-proline and C60-alanine had no toxic effect on HEp-2 cells. Sodium salt of polycarboxylic derivative of fullerene C60 exerted a pronounced toxic effect on this cell culture.
我们研究了富勒烯C60衍生物的细胞毒性。我们发现C60富勒烯与聚乙烯吡咯烷酮(聚乙烯吡咯烷酮分子量为10000和25000)、C60-NO2-脯氨酸和C60-丙氨酸的复合物对HEp-2细胞没有毒性作用。富勒烯C60的多羧酸衍生物钠盐对这种细胞培养物有明显的毒性作用。