Origoni M, Carminati G, Sideri M, Clementi M, Rolla S, Candiani M
Department of Gynecology & Obstetrics, Vita Salute San Raffaele University School of Medicine at San Raffaele Scientific Institute, Milano, Italy.
Eur J Gynaecol Oncol. 2012;33(3):261-4.
The correlation between high-risk HPV-DNA viral load, expressed as relative light units (RLU) values obtained from the Hybrid Capture 2 (HC2) test, and the prevalence of CIN2/CIN3 was investigated and statistically analyzed in 614 ASC-US consecutive cases. Cases were categorized into three groups according to RLU values: "low-grade positivity", "intermediate positivity" and "high-grade positivity", and the prevalence of CIN2/CIN3 was evaluated in the single groups and compared among them. CIN/CIN3 rates demonstrated a significant (p < 0.001) increase with a direct correlation with increasing RLU values: 4.6% (RLU from 1.0 to 10.0), 9.1% (RLU from 11.0 to 100.0) and 32.2% (RLU > 100.0) respectively. The prevalence of CIN2/CIN3 between the group with RLU < 10.0 (4.6%) and the group with RLU > 10 (24.2%) showed statistical significance (p = 0.0002). Increasing hrHPV viral load significantly correlates with increasing prevalence of CIN2/CIN3 in ASC-US cases.
在614例连续的非典型鳞状细胞意义不明确（ASC-US）病例中，研究并统计分析了以杂交捕获2代（HC2）检测获得的相对光单位（RLU）值表示的高危人乳头瘤病毒（HPV）-DNA病毒载量与宫颈上皮内瘤变2级/3级（CIN2/CIN3）患病率之间的相关性。根据RLU值将病例分为三组：“低度阳性”、“中度阳性”和“高度阳性”，评估单组中CIN2/CIN3的患病率并进行组间比较。CIN2/CIN3发生率显示出显著升高（p < 0.001），且与RLU值升高直接相关：分别为4.6%（RLU为1.0至10.0）、9.1%（RLU为11.0至100.0）和32.2%（RLU > 100.0）。RLU < 10.0组（4.6%）和RLU > 10组（24.2%）之间的CIN2/CIN3患病率具有统计学意义（p = 0.0002）。在ASC-US病例中，高危型HPV病毒载量增加与CIN2/CIN3患病率增加显著相关。
