Karahanoglu E, Adanir I, Boyraz G, Sahin N, Tuncer Z S
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Eur J Gynaecol Oncol. 2012;33(3):278-80.
Since leptin is believed to be a key player in carcinogenesis, a study has been designed to investigate the relationship between leptin levels and endometrial cancer.
A study including 30 patients with endometrial cancer and 30 healthy controls was carried out between November 2008 and July 2009 in Hacettepe University Hospital. All patients with endometrial cancer underwent a complete surgical staging procedure including lymphadenectomy. Preoperative leptin levels of endometrial cancer patients and healthy controls were compared. The relationships between leptin levels and stage, grade, histological type and lymph node status of endometrial cancer cases were evaluated.
The mean serum leptin levels were 16.9 ng/ml among endometrial cancer cases and 19.0 ng/ml among controls (p = 0.32). Of endometrial cancer cases, the mean leptin level was found to be 15.8 ng/ml for Stage I and 18.5 ng/ml for Stage II-IV disease (p = 0.34). The figure was 17.7 ng/ml for endometrioid and 13.2 ng/ml for non-endometrioid type of tumor (p = 0.24). The mean leptin levels of 16.3 ng/ml for grade 1 and 19.9 ng/ml for grade 2-3 tumors were observed (p = 0.07). The cases with positive and negative lymph nodes had leptin levels of 20.2 ng/ml and 16.1 ng/ml, respectively (p = 0.30).
Serum leptin levels in endometrial cancer patients were similar to healthy controls. Leptin did not show any significant correlation with stage, grade, histological type and node metastases in endometrial cancer.
由于瘦素被认为是致癌过程中的关键因素，因此设计了一项研究来调查瘦素水平与子宫内膜癌之间的关系。
2008年11月至2009年7月期间，在哈杰泰佩大学医院开展了一项研究，纳入30例子宫内膜癌患者和30名健康对照者。所有子宫内膜癌患者均接受了包括淋巴结清扫术在内的完整手术分期程序。比较了子宫内膜癌患者和健康对照者术前的瘦素水平。评估了瘦素水平与子宫内膜癌病例的分期、分级、组织学类型及淋巴结状态之间的关系。
子宫内膜癌病例的血清瘦素平均水平为16.9 ng/ml，对照组为19.0 ng/ml（p = 0.32）。在子宫内膜癌病例中，I期患者的瘦素平均水平为15.8 ng/ml，II-IV期疾病患者为18.5 ng/ml（p = 0.34）。子宫内膜样肿瘤的这一数字为17.7 ng/ml，非子宫内膜样肿瘤为13.2 ng/ml（p = 0.24）。观察到1级肿瘤的瘦素平均水平为16.3 ng/ml，2-3级肿瘤为19.9 ng/ml（p = 0.07）。淋巴结阳性和阴性的病例瘦素水平分别为20.2 ng/ml和16.1 ng/ml（p = 0.30）。
子宫内膜癌患者的血清瘦素水平与健康对照者相似。瘦素与子宫内膜癌的分期、分级、组织学类型及淋巴结转移均无显著相关性。
