Russell James A
Crit Care. 2012 Aug 8;16(4):146. doi: 10.1186/cc11393.
Smith and Perner report an observational cohort study of 164 patients with septic shock. For patients still alive on day 3, higher compared with lower fluid volume resuscitation was associated with lower 90-day mortality. This association of a relationship between fluid intake and decreased mortality aligns with the randomized controlled trial of early goal-directed therapy and later observational studies. I suggest careful individualization of fluid resuscitation to achieve adequate mean arterial pressure (about 60 to 70 mmHg) and normalization of arterial lactate levels in septic shock.
史密斯和佩尔纳报告了一项对164例感染性休克患者的观察性队列研究。对于在第3天仍存活的患者，较高液体量复苏与较低液体量复苏相比，90天死亡率更低。液体摄入量与死亡率降低之间的这种关联与早期目标导向治疗的随机对照试验及后来的观察性研究一致。我建议对液体复苏进行仔细个体化，以在感染性休克中实现足够的平均动脉压（约60至70 mmHg）和动脉乳酸水平正常化。
