Farese R V, Sabir A M
Biochim Biophys Acta. 1979 Nov 21;575(2):299-304. doi: 10.1016/0005-2760(79)90032-8.
As with adrenocorticotropin pretreatment in vivo, addition of cardiolipin in vitro enhances adrenal mitochondrial pregnenolone synthesis and apparent binding of cholesterol to cytochrome P-450scc. These effects are relatively specific for glycerolipids containing two or more phosphate radicals in the polar head group, and changes in such phospholipids or comparably acting substances may play a role in mediating adrenocorticotropin- or other hormone-induced effects on membrane-associated enzymes.
与体内促肾上腺皮质激素预处理一样，体外添加心磷脂可增强肾上腺线粒体孕烯醇酮的合成以及胆固醇与细胞色素P - 450scc的表观结合。这些效应对于极性头部基团含有两个或更多磷酸基团的甘油脂相对具有特异性，并且此类磷脂或具有类似作用的物质的变化可能在介导促肾上腺皮质激素或其他激素对膜相关酶的诱导效应中发挥作用。
