Department of Restorative Dentistry, Medical University of Bialystok, Poland.
Med Hypotheses. 2012 Oct;79(4):544-8. doi: 10.1016/j.mehy.2012.07.016. Epub 2012 Aug 6.
Xerostomia resulting mostly from hyposalivation and alkaline salivary pH is a frequent but often underappreciated symptom in the diseased population of maintenance hemodialysis (HD) patients. We reviewed also other xerostomia-predisposing factors, its specific dental and oral clinical signs and features, as well as plausibly detrimental dialysis-specific pro-atherosclerotic and cardiovascular consequences. In view of increasing multidisciplinary importance of xerostomia, its general, pharmacological and emerging treatment methods were presented. Special attention was paid to the untoward and often neglected pro-xerostomic effects of multiple common medications and substances; they were listed and described in more detail. The combined therapeutic approach of dentists and nephrologists may effectively alleviate xerostomia and support general health condition of maintenance hemodialysis patients.
口干症主要由唾液分泌减少和碱性唾液 pH 值引起，是维持性血液透析（HD）患者疾病人群中常见但常常被低估的症状。我们还回顾了其他口干症诱发因素、其特定的牙科和口腔临床体征和特征，以及可能对透析相关动脉粥样硬化和心血管产生有害影响的因素。鉴于口干症的多学科重要性日益增加，本文介绍了口干症的一般治疗、药物治疗和新兴治疗方法。特别关注了多种常见药物和物质通常被忽视的促口干作用，详细列出并描述了这些作用。牙医和肾病学家的联合治疗方法可以有效缓解口干症，改善维持性血液透析患者的整体健康状况。
