Department of Clinical Physiology and Exercise, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, UJM and PRES University of Lyon, France.
Sleep Med. 2012 Oct;13(9):1146-52. doi: 10.1016/j.sleep.2012.06.021. Epub 2012 Aug 6.
Some epidemiological data are available on the association between sleep duration and sleep quality, sleep complaints, and the aging related cognitive impairment in the elderly. In this study we examined a large sample of healthy elderly subjects to assess the relationship between sleep quality, subjective cognitive complaints, and neuropsychological performance.
A total of 272 elderly subjects (mean age 74.8 ± 1.1 years) were recruited from a population-based cross-sectional study on aging and cardiovascular morbidity. All subjects filled in self-assessment questionnaires evaluating cognitive function, anxiety, depression, sleep-related parameters, and the Pittsburgh Sleep Quality Index (PSQI). Ambulatory polygraphy and extensive neuropsychological tests were also performed. Based on the total PSQI score, subjects were classified as good sleepers (GS, PSQI<5, n=116) and poor sleepers (PS, PSQI≥5, n=156).
Poor sleep did not affect the subjective cognitive function score, subjective cognitive impairment being mainly related to anxiety, depression, and sleep medication intake. No significant differences were seen between GS and PS in any of the objective cognitive function tests except for the Trail Making Test A (TMA-A), processing speed being longer in the PS group (p<0.001). Neither the presence of sleep-related breathing disorders nor gender affected cognitive performance.
Our results suggest that in healthy elderly subjects, subjective sleep quality and duration did not significantly affect subjective and objective cognitive performances, except the attention level, for that the interference of sleep medication should be considered.
有一些关于睡眠时长和睡眠质量、睡眠主诉以及老年人认知功能障碍与衰老之间关系的流行病学数据。在这项研究中，我们检查了大量健康的老年人样本，以评估睡眠质量、主观认知主诉与神经心理学表现之间的关系。
共有 272 名老年人（平均年龄 74.8±1.1 岁）参与了一项关于衰老和心血管发病率的基于人群的横断面研究。所有受试者均填写了自我评估问卷，评估认知功能、焦虑、抑郁、睡眠相关参数和匹兹堡睡眠质量指数（PSQI）。还进行了动态多导睡眠图和广泛的神经心理学测试。根据 PSQI 总分，受试者被分为睡眠良好者（GS，PSQI<5，n=116）和睡眠不佳者（PS，PSQI≥5，n=156）。
睡眠不佳并不影响主观认知功能评分，主观认知障碍主要与焦虑、抑郁和睡眠药物摄入有关。在客观认知功能测试中，除了连线测试 A（TMA-A），PS 组的处理速度较慢（p<0.001）外，GS 和 PS 之间在任何一项测试中均无显著差异。睡眠呼吸障碍的存在或性别均不影响认知表现。
我们的研究结果表明，在健康的老年受试者中，主观睡眠质量和时长除了注意力水平外，不会显著影响主观和客观认知表现，应考虑睡眠药物的干扰。
