Department of Obstetrics, Hokkaido University Graduate School of Medicine, Kita-ku N14 W6, Sapporo 060-8638, Japan.
Arch Gynecol Obstet. 2013 Jan;287(1):9-14. doi: 10.1007/s00404-012-2501-5. Epub 2012 Aug 9.
To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR).
A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels.
The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among the four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3.132 ± 321 g; only one infant had FGR.
Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.
确定孕早期血清叶酸水平低是否会预测随后的晚期流产、早产或胎儿生长受限（FGR）。
一项前瞻性队列研究，共纳入 5075 名在孕早期测量血清叶酸水平的妇女。告知参与者其血清叶酸水平。
根据叶酸状态分类的四组之间，妊娠持续时间、出生体重、晚期流产/早产率和 FGR 率无显著差异。根据分娩时孕周分类的四分位血清叶酸水平无差异。20 名叶酸缺乏的妇女中，有 19 名足月分娩，婴儿出生体重为 3.132±321g；只有一名婴儿患有 FGR。
孕早期血清叶酸水平低与晚期流产、早产或 FGR 的风险无关。
