Zhao Xiaoxuan, Zhao Yang, Ping Yunlu, Chen Lu, Feng Xiaoling
Department of Heilongjiang University of Chinese Medicine, Harbin.
Hebei College of Traditional Chinese Medicine, Shijiazhuang.
Medicine (Baltimore). 2020 Oct 2;99(40):e21962. doi: 10.1097/MD.0000000000021962.
To evaluate the association between gene polymorphisms of MTHFR (C677T, A1298C) and MTRR (A66G), and the recurrent spontaneous abortion (RSA) risk in Asia.Related case-control studies were collected, selected, and screened. A meta-analysis was conducted by Stata 12.0 software to assess the association between polymorphisms of target genes and RSA.Altogether 30 studies examining the relationship between genetic polymorphism of folate metabolism and RSA risk were included, among which 20 studies were related to MTHFR C677T, 11 to MTHFR A1298C and 6 to MTRR A66G. The studies suggested that MTHFR C677T polymorphism was closely connected with RSA risk under all models (P < .05). Furthermore according to the subgroup analysis of ethnicity, the correlation between C677T polymorphism and RSA was stronger in north of China when compared with south of China and other Asian countries (P > . 05). For MTHFR A1298C, it was closely related to RSA risk in all gene models except for (AC vs AA) (P < .05). However, when it comes to MTRR A66G, there was no significant correlation between gene A66G polymorphism and RSA risk except for the additive gene model (G vs A) (P < .05).The present evidence shows that the correlation between gene polymorphisms and RSA risk can be found in MTHFR C677T, A1298C (except for heterozygote model) and MTRR A66G (only in additive genotypes), and the detection of the correlated gene polymorphisms mentioned above is of certain guiding significance for preventing RSA and screening high-risk groups.
评估亚甲基四氢叶酸还原酶（MTHFR，C677T、A1298C）和甲硫氨酸合成酶还原酶（MTRR，A66G）基因多态性与复发性自然流产（RSA）风险之间的关联。收集、选择并筛选相关病例对照研究。使用Stata 12.0软件进行荟萃分析，以评估目标基因多态性与RSA之间的关联。共纳入30项研究叶酸代谢基因多态性与RSA风险关系的研究，其中20项与MTHFR C677T相关，11项与MTHFR A1298C相关，6项与MTRR A66G相关。研究表明，在所有模型下，MTHFR C677T多态性与RSA风险密切相关（P＜0.05）。此外，根据种族亚组分析，与中国南方和其他亚洲国家相比，C677T多态性与RSA之间的相关性在中国北方更强（P＞0.05）。对于MTHFR A1298C，除（AC与AA）外，在所有基因模型中均与RSA风险密切相关（P＜0.05）。然而，对于MTRR A66G，除加性基因模型（G与A）外，基因A66G多态性与RSA风险之间无显著相关性（P＜0.05）。现有证据表明，MTHFR C677T、A1298C（杂合子模型除外）和MTRR A66G（仅在加性基因型中）的基因多态性与RSA风险之间存在相关性，检测上述相关基因多态性对预防RSA和筛查高危人群具有一定指导意义。
